Naftifine hydrochloride ointment,physical properties,suppliers,cas,msds,structure,molecular formula, molecular weight,solubility,boiling point, melting point. Naftin naftifine dosing, indications, interactions. Naftifine hydrochloride 2% cream results in clinical cure rate and clinical success rate of 33% and 84% after treatment for 4 weeks, and week 2 efficacy response rates in naftifine hydrochloride 2% subjects are all lower than at week 4 but are significantly higher than week 2 vehicletreated counterparts 3. Sds of naftifine hydrochloride, safety data sheets, cas. Naftifine hcl generic is the generic alternative to naftin cream. Material may be irritating to the mucous membranes and upper respiratory tract. The role of naftifine hcl 2% gel and cream in treating. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not.
Naftifine hydrochloride, chemical structure, molecular. Extinguishing media extinguish with water spray, carbon dioxide, dry chemical or material appropriate for the surrounding fire. Persons hypersensitive to any of the ingredients in this product may. Pdf efficacy and safety of naftifine hcl gel 2% in the. First aid measures description of first aid measures. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol. Naftifine hcl definition of naftifine hcl by medical dictionary. Your doctor may recommend naftifine hcl, an antifungal cream, to get rid of a fungal or yeast skin infection, such as athletes foot, ringworm, or jock itch. Naftifine hcl 1% may cause adverse effects in patients with certain health conditions. Contains nonbinding recommendations draft guidance on naftifine hydrochloride recommended jan 2016 this draft guidance, when finalized, will represent the current thinking of the food and drug. If you feel that naftifine hcl 1% is being ineffective, consult your doctor who may increase your dosage or change your treatment. Naftifine hydrochloride 50, 500 mg in poly bottle sigma. Material safety data sheet methanol section 1 chemical product and company identification msds name.
Dec 23, 2019 provides accurate and independent information on more than 24,000 prescription drugs, overthecounter medicines and natural products. For additional savings, you can always purchase naftifine hcl generic instead of naftifine hcl 1% from. Naftifine hydrochloride monograph for professionals. The following in vitro data are available, but their clinical significance is unknown. Naftifine hydrochloride safety data sheet section 2. Have eyes examined and tested by medical personnel.
Chemically, naftifine hcl is encinnamylnmethyl1napthalenemethylamine hydrochloride. Feb 01, 2016 naftifine hydrochloride cream, 2% has been investigated for safety and efficacy in a randomized, doubleblind, vehiclecontrolled, multicenter study in 146 subjects with symptomatic and dermatophyte culture positive tinea cruris. Special hazards arising from the substance or mixture. Do not apply dressings, bandages, cosmetics, lotions, or other skin medications to the area being treated unless your doctor tells you. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells. Pooled results from two multicenter, randomized, doubleblind, vehicle. Sds of naftifine hydrochloride, safety data sheets, cas 65473. Hydrochloric acid uk oes stel 7 mgm3 10 minutes usa osha pel 7 mgm3 ceiling usa acgih 7 mgm3 tlv ceiling usa niosh 7 mgm3 ceiling canada tlv 7 mgm3 osha idlh 50 ppm vle france stel 7. Naftin 2% cream safety data sheet sds sds revision date. Never give anything by mouth to an unconscious person. Each gram of naftifine hydrochloride cream contains 20 mg of naftifine hydrochloride, a synthetic allylamine antifungal compound. Take naftifine hcl 1% exactly as directed by your doctor. Allylamine compound that has antifungal and antimycotic activities. Naftifine hydrochloride cream usp, 2% is a white to offwhite cream for topical use only.
Buy naftifine, hydrochloride cas 65473145, an antifungal agent. Naftifined3 hydrochloride scbt santa cruz biotechnology. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing. Naftin naftifine hydrochloride gel naftin naftifine. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3epoxidase. This material does not contain any class 1 ozone depletors. Subjects were randomized to receive naftifine hydrochloride cream or vehicle. Talk to your doctor if naftifine hcl 1% is right for you. In recent years, new topical antifungals have emerged for the treatment and management of tinea pedis, but all have been investigated and approved for the treatment of interdigital tinea pedis.
The clinical trials of naftifine hcl 2% with daily administration for 2 weeks showed equivalence with the 1% formulation administered for 4 weeks. Calculate the percentage of each impurity in the portion of naftifine hydrochloride taken by the formula. Buy naftifine, hydrochloride cas 65473145, an antifungal agent, from santa cruz. Naftifine andor its metabolites are excreted via the urine and feces with a halflife of approximately two to three days. Following topical application, measurable concentrations of naftifine are absorbed into the plasma and the drug penetrates the stratum corneum in sufficient quantities to inhibit growth of dermatophytes. In recent years, new topical antifungals have emerged for the. Naftin naftifine hydrochloride cream is a topical for the skin antifungal medication used to treat skin infections such as athletes foot, jock itch, and ringworm infections. Hydrochloric acid, 10% vv safety data sheet according to federal register vol. Naftifine is an allylamine compound that blocks ergosterol biosynthesis in fungi by inhibiting squalene epoxidase k i 1. Naftifine cream fda prescribing information, side effects. Naftifine hydrochloride 2% cream results in clinical cure rate and clinical success rate of 33% and 84% after treatment for 4 weeks, and week 2 efficacy response rates in naftifine hydrochloride 2% subjects. Naftin cream 1% and gel 1% naftifine hydrochloride dose.
Immediately wash skin with soap and plenty of water for at least 15. Naftin 1% gel safety data sheet sds sds revision date. Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. Naftifine comes as a cream and gel to apply to the skin. Some infections require up to 6 weeks of treatment. Individuals sensitive to naftifine hydrochloride or hypersensitivity to any of the components in the formulation.
Do not let naftifine get into your eyes, nose or mouth, and do not swallow it. It is an antimycotic allylamine and antifungal agent. Each gram of naftifine hydrochloride cream usp, 2% contains 20 mg of naftifine hydrochloride 2%, a synthetic allylamine antifungal compound. Naftin cream is a white to offwhite cream for topical use only. This drug may also be called naftifine hydrochloride. Subjects were randomized to receive naftifine hydrochloride. Hydrochloric acid, 37% ww 7647010 ec50 daphnia 1 naftifine hcl 2% gel and cream in treating moccasin tinea pedis. Following topical application, approximately 36% absorbed. Description of first aid measures general in all cases of doubt, or when symptoms persist, seek medical attention. Apply a thin layer of the medication to and around the affected area and.
Naftifine hydrochloride 50, 500 mg in poly bottle sigmaaldrich. Side effects of naftin cream naftifine hcl, warnings, uses. Naftifine hydrochloride cream, 2% is a white to offwhite cream for topical use only. Buy naftifine hcl 1 % online generic naftifine hcl 1 %. Naftifine hydrochloride ointment,physical properties.
You must check to make sure that it is safe for you to take naftifine with all of your drugs and health problems. Extinguishing media extinguish with water spray, carbon. Naftifine hydrochloride pharmacokinetics absorption bioavailability. If irritation, skin rash, or sensitivity occurs during use of naftifine. Sds of naftifine hydrochloride, safety data sheets, cas 65473145. Dec 21, 2018 naftin gel, 1% contains the synthetic, broadspectrum, antifungal agent naftifine hydrochloride. Standard preparation dissolve an accurately weighed quantity of usp naftifine hydrochloride rs in mobile phase, and dilute quantitatively, and stepwise, if necessary, with mobile phase to obtain a solution having a known concentration of about 0. Naftifine hydrochloride cream, 2% has been investigated for safety and efficacy in a randomized, doubleblind, vehiclecontrolled, multicenter study in 146 subjects with symptomatic and dermatophyte culture positive tinea cruris. A broadspectrum antifungal agent used in the topical treatment of tinea infections. Each gram of naftifine hydrochloride cream contains 20 mg of naftifine hydrochloride 2%, a synthetic allylamine antifungal compound chemically, naftifine hcl is encinnamylnmethyl1napthalenemethylamine hydrochloride. Naftin naftifine dosing, indications, interactions, adverse. Safety data sheet according to federal register vol. May 08, 2018 a comprehensive guide to side effects including common and rare side effects when taking naftin cream naftifine hcl includes uses, warnings, and drug interactions.
Material safety data sheet of naftifine hydrochloride. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not start, stop, or change the dose of any drug without checking with your doctor. To buy naftifine hcl 1% a doctors prescription may be required. Material safety data sheet of naftifine hydrochloride contains identification of substance and details of the supplier of the safety data sheet. Hold eyelids apart and flush eyes with plenty of water for at least 15. Following single topical applications of 3 hlabeled naftifine gel 1% to the skin of healthy subjects, up to 4. Naftin gel, 1% is indicated for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms trichophyton rubrum, trichophyton. Chemical name encinnamylnmethyl1naphthalenemethylamine hydrochloride. Naftifine is contraindicated in patients that have a known or suspected hypersensitivity to naftifine or any of the components of the formulation. Naftifine hydrochloride is a synthetic allylamine derivative. Naftifine is an antifungal that works by preventing the growth of fungus. Safety data sheet according to 29cfr19101200 and ghs rev.
Tell all of your health care providers that you take naftifine. What are some things i need to know or do while i take naftifine. The structural formula of naftifine hydrochloride is. The naftifine hcl medication you purchase is manufactured by sandoz.
Naftifine hydrochloride has an empirical formula of c 21 h 21 nhcl and a molecular weight of 323. The cream is usually used once a day and the gel twice a day in the morning and evening for 2 to 4 weeks. Efficacy and safety of naftifine hcl gel 2% in the treatment of interdigital and moccasin type tinea pedis. At last,naftifine hydrochloride65473145 safety, risk, hazard and msds, cas,cas number,use,cas no may also be you need. Naftifine hydrochloride has been shown to exhibit fungicidal activity in vitro against a broad spectrum of organisms, including trichophyton rubrum, trichophyton mentagrophytes, trichophyton tonsurans, epidermophyton. This drug may also be called naftifine hydrochloride cream, naftin cream, or naftinmp cream. Material safety data sheet hydrochloric acid section 1 chemical product and company identification msds name. The role of naftifine hcl 2% gel and cream in treating moccasin tinea pedis.